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Free, publicly-accessible full text available June 1, 2026
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Preferential attachment (PA) network models have a wide range of applications in various scientific disciplines. Efficient generation of large-scale PA networks helps uncover their structural properties and facilitate the development of associated analytical methodologies. Existing software packages only provide limited functions for this purpose with restricted configurations and efficiency. We present a generic, user-friendly implementation of weighted, directed PA network generation with R package wdnet. The core algorithm is based on an efficient binary tree approach. The package further allows adding multiple edges at a time, heterogeneous reciprocal edges, and user-specified preference functions. The engine under the hood is implemented in C++. Usages of the package are illustrated with detailed explanation. A benchmark study shows that wdnet is efficient for generating general PA networks not available in other packages. In restricted settings that can be handled by existing packages, wdnet provides comparable efficiency.more » « less
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ABSTRACT We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve chromosome-level contiguity with unparalleled sequence accuracy (<1 error in 500,000 base pairs), completely sequencing 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, providing more in-depth evolutionary insights. Comparative analyses, including human, allow us to investigate the evolution and diversity of regions previously uncharacterized or incompletely studied without bias from mapping to the human reference. This includes newly minted gene families within lineage-specific segmental duplications, centromeric DNA, acrocentric chromosomes, and subterminal heterochromatin. This resource should serve as a definitive baseline for all future evolutionary studies of humans and our closest living ape relatives.more » « less
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